First Hospital West of the Mississippi River

Historical marker location:

413 S 4th St, Saint Louis, Missouri

( Marker is on South 4th Street just south of Spruce Street, on the right when traveling east.)

Marker installed: 1988

The Missouri State Penitentiary, located in Jefferson City, was once the oldest operating prison west of the Mississippi River. It opened in 1836 and closed in 2004.